Mucin associated Tn and sialosyl-Tn antigen expression in colorectal polyps.
نویسندگان
چکیده
منابع مشابه
Mucin associated Tn and sialosyl-Tn antigen expression in colorectal polyps.
Sialosyl-Tn antigen and its immediate precursor, Tn antigen, are carbohydrate structures associated with the earliest steps of mucin O-linked glycosylation. Both antigens have been shown previously to be highly sensitive and specific markers of colorectal cancer. One hundred and three colorectal polyps (79 adenomatous; 24 hyperplastic) were examined for expression of Tn antigen using vicia vill...
متن کاملExpression of Tn, sialosyl-Tn, and T antigens in human colon cancer.
Mucin glycoproteins are major secretory products of the colon and contain O-linked oligosaccharides synthesized on a polypeptide backbone. The initial step in the synthesis of O-linked oligosaccharides is the addition of N-acetylgalactosamine to serine or threonine residues forming the Tn antigen. This substance can then receive additional carbohydrate residues such as sialic acid to form sialo...
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The sialosyl-Tn (Sin) antigen is a mucin-associated carbohydrate antigen expressed by a variety of adenocarcinomas. In the colon, ex pression of this antigen has been associated with a poor prognosis, independent of tumor stage or histology. The present study was per formed to determine whether this adverse clinical outcome might be due to an interaction between STn-positive murili and natural ...
متن کاملExpression profile of mucin-associated sialyl-Tn antigen in Chinese patients with different colorectal lesions (adenomas, carcinomas).
BACKGROUND The sialyl-Tn (sTn) antigen is a mucin-associated carbohydrate antigen expressed by numerous human carcinomas, and is also claimed to be a prognostic factor in colorectal cancer. But the associations between sTn and colorectal cancer remain elusive and controversial. Here, we investigated the expression profile of sTn antigen in a series of human colorectal tissue samples including n...
متن کاملUse of model cell lines to study the biosynthesis and biological role of cancer-associated sialosyl-Tn antigen.
Sialosyl-Tn (STn) is a mucin-associated carbohydrate antigen that is not expressed by most normal epithelial cells but becomes expressed in several types of adenocarcinomas, where it is often associated with a poor prognosis. Little is known about the regulation of the STn phenotype in tumor cells and the immune response to STn antigen. In the present study, we established clonal cell lines in ...
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ژورنال
عنوان ژورنال: Gut
سال: 1992
ISSN: 0017-5749
DOI: 10.1136/gut.33.4.518